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Homocysteine as a Predictor of Hypertensive Disorders of Pregnancy
Ramon Vargas-Vera,
Martha Placencia-Ibadango,
Kalid Vargas-Silva,
Noren Villalobos Inciarte,
Daniela Zalamea-Holguin,
Saul Alencastro-Placencia,
Eneida Encalada-Moreira
Issue:
Volume 8, Issue 1, March 2022
Pages:
1-7
Received:
30 November 2021
Accepted:
11 January 2022
Published:
14 April 2022
Abstract: Homocysteine is an amino acid that is a product of methionine metabolism, it is related to preeclampsia in 20-30%, the increase of this or hyperhomocysteinemia may result from the genetic defect of the enzyme methylenetetrahydrofolate reductase involved in the synthesis of homocysteine. Maternal mortality due to preeclampsia is up to 44% and perinatal mortality is reported at up to 27.8%. The objective of this research was to determine homocysteine levels as a predictor of preeclampsia in pregnant women that have 12 to 20 weeks. This was an observational, longitudinal and prospective investigation. The study population were patients attending the first prenatal care consultation between the 12th to 20th weeks, the sample was random and it included 360 patients from whom it was determined their serum homocysteine level. The study excluded 48 patients who did not meet the inclusion and exclusion criteria; it was found homogeneity among the patients, 270 patients (86.5%) had a normal evolution at pregnancy, 27 patients (8.65%) had gestational hypertension, 9 (2.88%) mild preeclampsia and 6 patients (1.9%) severe preeclampsia, none developed HELLP syndrome. Increased homocysteine levels were found in 9 patients who were not related to hypertensive pregnancy disorders. In the present research, homocysteine was not shown to be a predictor of hypertensive disease in pregnancy.
Abstract: Homocysteine is an amino acid that is a product of methionine metabolism, it is related to preeclampsia in 20-30%, the increase of this or hyperhomocysteinemia may result from the genetic defect of the enzyme methylenetetrahydrofolate reductase involved in the synthesis of homocysteine. Maternal mortality due to preeclampsia is up to 44% and perina...
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Ten Years Trend Analysis of Malaria Prevalence in Ziway Dugda District, Arsi Zone, Ethiopia
Million Getachew Mesfun,
Shimelis Teshome Ayalneh
Issue:
Volume 8, Issue 1, March 2022
Pages:
8-11
Received:
7 March 2022
Accepted:
9 April 2022
Published:
20 April 2022
Abstract: Background: Malaria has been one of the major public health problems in Ethiopia for decades. Recent reports from different part of the country showed that the trend of malaria is declining. However, there is a need for periodic assessing the trend of malaria in different malaria endemic areas of the country as part of the planed malaria elimination strategies. Methods: Ten years retrospective data of blood film examination was collected from the laboratory registration book and monthly report of Ogolcho health center and analyzed to assess the trend of malaria prevalence in Ziway dugda distric, one of the malaria endemic areas in Arsi zone, Ethiopia. Result: From the total of 38,094 malaria suspected patients, 4,863 (12.8%) patients were malaria positive microscopically, with 3,301 (67.9%) P. vivax, 1545 (31.8%) P. falciparum and 17 (0.35%) mixed infection. There was a fluctuating trend of malaria within the last ten years, with annual total cases of malaria ranged from 1685 in 2013 to 103 in 2020 and there was successive reduction in malaria prevalence from 2013 onwards. Conclusion: Trend of malaria was declining in Ziway dugda district with shift in dominancy of the circulating species (P. vivax).
Abstract: Background: Malaria has been one of the major public health problems in Ethiopia for decades. Recent reports from different part of the country showed that the trend of malaria is declining. However, there is a need for periodic assessing the trend of malaria in different malaria endemic areas of the country as part of the planed malaria eliminatio...
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A Retrospective Cohort Study on Using Fully Threaded, Cortical Screws in Locking SIGN Intramedullary Nails
Christian Emmanuel Marbella Fontanilla,
Romer Ariel Minor Santos
Issue:
Volume 8, Issue 1, March 2022
Pages:
12-14
Received:
22 March 2022
Accepted:
11 April 2022
Published:
20 April 2022
Abstract: The Surgical Implant Generation Network (SIGN) produces solid and straight intramedullary nails used for femoral or tibial fractures. These utilize interlocking screws with proximal and distal threads to purchase at the cortices. When SIGN interlocking screws are unavailable, 4.5 mm, fully threaded, stainless steel, cortical screws are sometimes used to lock the nails. This study compared the alignment, fracture healing, and screw failure rates between cases which solely used SIGN interlocking screws and those which incorporated fully threaded, cortical screws. The SIGN census from January 2018 to August 2021 was reviewed. 79 cases were included in this study. 59 solely used SIGN interlocking screws and 20 incorporated fully threaded, cortical screws. The former group had acceptable alignment in 91.5%, 3-4 bridging cortices by the 12th week in 81.4%, and no screw failure in 96.8%. The latter group had acceptable alignment in 90.0%, 3-4 bridging cortices by the 12th week in 80.0%, and no screw failure in 95.0% of cases. The chi-square test showed no significant difference in outcomes between the two groups with p= .836 for fracture alignment, p= .894 for fracture healing, p= .745 for screw failure. This study concluded that 4.5 mm, fully threaded, stainless steel, cortical screws may be incorporated to lock SIGN nails when SIGN interlocking screws are unavailable.
Abstract: The Surgical Implant Generation Network (SIGN) produces solid and straight intramedullary nails used for femoral or tibial fractures. These utilize interlocking screws with proximal and distal threads to purchase at the cortices. When SIGN interlocking screws are unavailable, 4.5 mm, fully threaded, stainless steel, cortical screws are sometimes us...
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