International Journal of Biomedical Engineering and Clinical Science

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Predicative Meaning of Radioiodine Pharmacokinetics Indices for Evaluation of Radioablation Efficacy of Thyroid Residuum in Patients with Differentiated Thyroid Cancer

Received: 12 June 2023    Accepted: 6 July 2023    Published: 20 July 2023
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Abstract

Background: The radioiodine ablation (RIA) of thyroid residuum in patients with differentiated thyroid cancer (DTC) is an important stage of complex treatment. The aim of RIA is the elimination of potential foci of DTC and creating conditions for monitoring of the patients. Prognosis of the efficacy of RIA is important for further planning of the complex treatment. The aim of the study was to improve a prognosis of RIA of thyroid residual tissue (TRT) in patients with DTC using scintigraphic date about 131I kinetics, that reflect a radioresistance of a thyroid tissue. Material and Methods: The results of RIA of TRT in 62 patients were analyzed. During radioiodine therapy (RIT) the elimination halftime of 131I from TRT in time interval 3–6 days after administration of therapeutic activities was determined, and the focal radiation adsorbed doses (FRAD) in TRT were calculated. Results: It was determined that values Т1/2 ≥ 4.0 days may indicate on the high probability of the incomplete RIA of TRT at FRAD within 50–500 Gy, while values Т1/2 ≤ 1.9 days – on the radiosensitivity of the thyroid tissue and the great probability of the complete RIA. Conclusions: During RIT of DCT the elimination halftime of iodine-131, determined on time interval 3–6 days after the administration of therapeutic activities may be used as one of predicative indices of RIA efficacy. Since the elimination halftime of the radiopharmaceutical reflects the individual natural radiosensitivity of TRT, this approach may be applied in studies of the radioresistance of a normal human tissue.

DOI 10.11648/j.ijbecs.20230903.14
Published in International Journal of Biomedical Engineering and Clinical Science (Volume 9, Issue 3, September 2023)
Page(s) 56-59
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Differentiated Thyroid Cancer, Radioiodine Therapy, Radioiodine Ablation, Residual Thyroid Tissue, Prognosis of Radioiodine Ablation Efficacy

References
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[11] Wierts R, Brans B, Havekes B, Kemerink GJ, Halders SG, Schaper NN, Backes WH, Mottaghy FM, Jentzen W (2016) Dose-response relationship in differentiated thyroid cancer patients undergoing radioiodine treatment assessed by means of 124I PET/CT. J Nucl Med 57: 1027–1032. doi. org/10.2967/jnumed.115.168799.
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    Dmitry Dzhuzha. (2023). Predicative Meaning of Radioiodine Pharmacokinetics Indices for Evaluation of Radioablation Efficacy of Thyroid Residuum in Patients with Differentiated Thyroid Cancer. International Journal of Biomedical Engineering and Clinical Science, 9(3), 56-59. https://doi.org/10.11648/j.ijbecs.20230903.14

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    Dmitry Dzhuzha. Predicative Meaning of Radioiodine Pharmacokinetics Indices for Evaluation of Radioablation Efficacy of Thyroid Residuum in Patients with Differentiated Thyroid Cancer. Int. J. Biomed. Eng. Clin. Sci. 2023, 9(3), 56-59. doi: 10.11648/j.ijbecs.20230903.14

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    AMA Style

    Dmitry Dzhuzha. Predicative Meaning of Radioiodine Pharmacokinetics Indices for Evaluation of Radioablation Efficacy of Thyroid Residuum in Patients with Differentiated Thyroid Cancer. Int J Biomed Eng Clin Sci. 2023;9(3):56-59. doi: 10.11648/j.ijbecs.20230903.14

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  • @article{10.11648/j.ijbecs.20230903.14,
      author = {Dmitry Dzhuzha},
      title = {Predicative Meaning of Radioiodine Pharmacokinetics Indices for Evaluation of Radioablation Efficacy of Thyroid Residuum in Patients with Differentiated Thyroid Cancer},
      journal = {International Journal of Biomedical Engineering and Clinical Science},
      volume = {9},
      number = {3},
      pages = {56-59},
      doi = {10.11648/j.ijbecs.20230903.14},
      url = {https://doi.org/10.11648/j.ijbecs.20230903.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20230903.14},
      abstract = {Background: The radioiodine ablation (RIA) of thyroid residuum in patients with differentiated thyroid cancer (DTC) is an important stage of complex treatment. The aim of RIA is the elimination of potential foci of DTC and creating conditions for monitoring of the patients. Prognosis of the efficacy of RIA is important for further planning of the complex treatment. The aim of the study was to improve a prognosis of RIA of thyroid residual tissue (TRT) in patients with DTC using scintigraphic date about 131I kinetics, that reflect a radioresistance of a thyroid tissue. Material and Methods: The results of RIA of TRT in 62 patients were analyzed. During radioiodine therapy (RIT) the elimination halftime of 131I from TRT in time interval 3–6 days after administration of therapeutic activities was determined, and the focal radiation adsorbed doses (FRAD) in TRT were calculated. Results: It was determined that values Т1/2 ≥ 4.0 days may indicate on the high probability of the incomplete RIA of TRT at FRAD within 50–500 Gy, while values Т1/2 ≤ 1.9 days – on the radiosensitivity of the thyroid tissue and the great probability of the complete RIA. Conclusions: During RIT of DCT the elimination halftime of iodine-131, determined on time interval 3–6 days after the administration of therapeutic activities may be used as one of predicative indices of RIA efficacy. Since the elimination halftime of the radiopharmaceutical reflects the individual natural radiosensitivity of TRT, this approach may be applied in studies of the radioresistance of a normal human tissue.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Predicative Meaning of Radioiodine Pharmacokinetics Indices for Evaluation of Radioablation Efficacy of Thyroid Residuum in Patients with Differentiated Thyroid Cancer
    AU  - Dmitry Dzhuzha
    Y1  - 2023/07/20
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ijbecs.20230903.14
    DO  - 10.11648/j.ijbecs.20230903.14
    T2  - International Journal of Biomedical Engineering and Clinical Science
    JF  - International Journal of Biomedical Engineering and Clinical Science
    JO  - International Journal of Biomedical Engineering and Clinical Science
    SP  - 56
    EP  - 59
    PB  - Science Publishing Group
    SN  - 2472-1301
    UR  - https://doi.org/10.11648/j.ijbecs.20230903.14
    AB  - Background: The radioiodine ablation (RIA) of thyroid residuum in patients with differentiated thyroid cancer (DTC) is an important stage of complex treatment. The aim of RIA is the elimination of potential foci of DTC and creating conditions for monitoring of the patients. Prognosis of the efficacy of RIA is important for further planning of the complex treatment. The aim of the study was to improve a prognosis of RIA of thyroid residual tissue (TRT) in patients with DTC using scintigraphic date about 131I kinetics, that reflect a radioresistance of a thyroid tissue. Material and Methods: The results of RIA of TRT in 62 patients were analyzed. During radioiodine therapy (RIT) the elimination halftime of 131I from TRT in time interval 3–6 days after administration of therapeutic activities was determined, and the focal radiation adsorbed doses (FRAD) in TRT were calculated. Results: It was determined that values Т1/2 ≥ 4.0 days may indicate on the high probability of the incomplete RIA of TRT at FRAD within 50–500 Gy, while values Т1/2 ≤ 1.9 days – on the radiosensitivity of the thyroid tissue and the great probability of the complete RIA. Conclusions: During RIT of DCT the elimination halftime of iodine-131, determined on time interval 3–6 days after the administration of therapeutic activities may be used as one of predicative indices of RIA efficacy. Since the elimination halftime of the radiopharmaceutical reflects the individual natural radiosensitivity of TRT, this approach may be applied in studies of the radioresistance of a normal human tissue.
    VL  - 9
    IS  - 3
    ER  - 

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Author Information
  • Department of Nuclear Medicine, Nonprofit Organisation National Cancer Institute of Ministry of Health of Ukraine, Kyiv, Ukraine

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